Let’s open Excel in application Safe Mode and check how it works. To do that, press the ‘Windows + R’ key on the keyboard.

In the Run open box type in ‘Excel /safe’ and hit ok.  

     Note: There is a space between excel and /.

If application safe mode works, try disabling the add-ins associated with Office applications and check.

To do that, do the following:

     01. Open Word or Excel Click on File and then click on options.

     02. In the Options Window click on Add-ins.

     03. Select Com Add-ins in the Manage list in the Add-ins section and click Go. Now uncheck the all the add-ins and click Ok.

If the issue still persist, you may refer to the suggestions from the below Microsoft article to repair Office 2016 and check if it helps resolve the issue:

http://office.microsoft.com/en-in/project-help/repair-or-remove-office-HA010357402.aspx